For best results, take the recommended dosage of Cissus Quadrangularis 750 mg + Calcium Citrate Maleate 500 mg + Calcitriol 0.25 mcg + Cyanocobalamin 7.5 mcg as advised by your healthcare provider. It is typically taken once or twice a day, preferably with a meal to aid in absorption and prevent any potential stomach discomfort.